FLRT3

Across TCGA pan-cancer cohorts, FLRT3 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated FLRT3 data layer compared with 28 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher FLRT3 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated FLRT3 expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCEC show a favorable association.

HNSC, LUAD, and CCRCC are the cancer types where FLRT3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	All	0.962	0.818	.026	7	view →
LUAD	DFS	Tertile	III,IV	0.498	0.968	.031	5	view →
CCRCC	OS	Median	IV	0.150	0.785	.040	4	view →
PDAC	OS	Median	All	0.749	0.903	.007	4	view →
UCEC	OS	Median	All	0.973	0.864	.036	4	view →
LSCC	DFS	Median	II,III,IV	0.575	0.822	.017	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

FLRT3–HNSC (OS)

Open the HNSC breakdown →