Across TCGA patient cohorts, FLRT2 mutation is significantly associated with the RNA expression of many other genes, with 7,193 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FLRT2-associated genes across cancer lineages are PELP1, MIS18A, and RPL23AP53. Each is linked with FLRT2 in more than 4 cancer types. Because this analysis shows association rather than direction, both FLRT2-to-partner and partner-to-FLRT2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FLRT2→partner) and Y-score (partner→FLRT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PELP1 →	+0.327	+2.375	.001	<.001	3	5
READ	MIS18A →	+0.583	+3.376	.001	.003	3	5
UCEC	RPL23AP53 →	+0.326	+1.115	<.001	.001	3	5
UCEC	SNW1 →	+0.298	+1.576	.002	<.001	3	4
READ	KNOP1 →	+0.478	+3.603	<.001	.001	3	4
UCEC	NDUFC1 →	+0.270	+1.343	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,193 associations by consensus.

Exploration

FLRT2 survival (RNA) · tumor vs normal (RNA) · all FLRT2 data types