Across TCGA patient cohorts, FLRT2 mutation is significantly associated with the total protein of many other genes, with 91 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FLRT2-associated genes across cancer lineages are eIF4E, PAI-1, and ATM. Each is linked with FLRT2 in more than 4 cancer types. Because this analysis shows association rather than direction, both FLRT2-to-partner and partner-to-FLRT2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FLRT2→partner) and Y-score (partner→FLRT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.169	+2.083	.001	<.001	3	5
LUAD	PAI-1 →	+0.619	+3.000	.049	.034	3	4
UCEC	ATM →	-0.431	-1.764	<.001	.001	3	4
READ	p27_pT157 →	+0.110	+2.842	.040	.029	3	4
UCEC	MEK1 →	+0.374	+2.874	<.001	<.001	3	4
STAD	Cyclin-E2 →	+0.158	+1.606	.002	.041	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 91 associations by consensus.

Exploration

FLRT2 survival (RNA) · tumor vs normal (RNA) · all FLRT2 data types