FLRT1

Across TCGA pan-cancer cohorts, FLRT1 Mutation is linked to patient survival in 10 of 34 cancer types, making it a survival-associated FLRT1 data layer compared with 23 for mass-spec protein.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher FLRT1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated FLRT1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and STAD show a favorable association.

LIHC, COAD, and UVM are the cancer types where FLRT1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	OS	Median	All	0.184	0.786	<.001	24	view →
COAD	OS	Median	III,IV	0.163	0.791	.004	14	view →
UVM	OS	Median	All	0.248	0.769	.007	12	view →
BLCA	OS	Median	IV	0.051	0.600	<.001	12	view →
GBM	OS	Median	All	0.030	0.416	<.001	9	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
LUSC	OS	Median	All	0.176	0.724	.018	6	view →
UCEC	DFS	Median	All	0.928	0.618	.017	6	view →
KIRP	OS	Median	All	0.135	0.703	.020	3	view →
STAD	DFS	Median	II,III,IV	1.000	0.369	.043	3	view →

Pink = unfavorable, green = favorable. Showing the 10 strongest of 10 lineages.

FLRT1–LIHC (OS)

Open the LIHC breakdown →