FLOT2

Across TCGA patient cohorts, FLOT2 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FLOT2-associated genes across cancer lineages are ATM, PDCD4, and 4E-BP1. Each is linked with FLOT2 in more than 2 cancer types. Because this analysis shows association rather than direction, both FLOT2-to-partner and partner-to-FLOT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by FLOT2-low versus FLOT2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FLOT2→partner) and Y-score (partner→FLOT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.448	-2.584	.010	.001	3	3
UCEC	PDCD4 →	-0.434	-1.678	.016	.023	3	2
UCEC	4E-BP1 →	+0.218	+3.489	.036	.002	3	2
UCEC	14-3-3_beta →	-0.076	-1.847	.049	.049	3	1
UCEC	eEF2 →	+0.331	+1.678	.015	.023	3	1
UCEC	EGFR_pY1068 →	-0.224	-2.087	.019	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

ATM by FLOT2 expression — UCEC

Explore this box plot interactively →