FLOT2

Across TCGA cell cohorts, FLOT2 mutation is significantly associated with the RNA expression of many other genes, with 110 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FLOT2-associated genes across cancer lineages are ABCG4, OXT, and CST4. Each is linked with FLOT2 in more than 1 cancer types. Because this analysis shows association rather than direction, both FLOT2-to-partner and partner-to-FLOT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ABCG4 grouped by FLOT2-low versus FLOT2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FLOT2→partner) and Y-score (partner→FLOT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ABCG4 →	+0.352	+3.674	<.001	.001	3	2
SKIN	OXT →	+0.038	+3.562	<.001	.002	3	2
SKIN	CST4 →	+0.317	+3.938	<.001	.002	3	2
SKIN	FSHR →	+0.066	+3.103	<.001	.004	3	2
SKIN	ADH1A →	+0.040	+3.669	.002	<.001	3	2
SKIN	GAB4 →	+0.097	+3.716	.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 110 associations by consensus.

ABCG4 by FLOT2 expression — LARGE_INTESTINE

Explore this box plot interactively →