FLOT1

Across TCGA pan-cancer cohorts, FLOT1 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of FLOT1’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where FLOT1 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types FLOT1 is over-expressed in tumor, although a few such as COAD and LUAD show the opposite, repressed pattern.

CCRCC, COAD, and PDAC are the cancer types where FLOT1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FLOT1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Male	III,IV	+0.450	<.001	11	view →
COAD	Male	III,IV	−0.311	<.001	11	view →
PDAC	Female	II,III,IV	+0.359	<.001	7	view →
LUAD	Male	All	−0.164	<.001	5	view →
LSCC	Male	II,III,IV	−0.280	<.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

FLOT1–CCRCC

Open the CCRCC breakdown →