FLNC

Across TCGA pan-cancer cohorts, FLNC mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated FLNC data layer compared with 28 for mass-spec protein and 12 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher FLNC mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated FLNC expression acts as an unfavorable survival marker.

CCRCC, GBM, and PDAC are the cancer types where FLNC mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	III,IV	0.105	0.928	.003	44	view →
GBM	OS	Tertile	All	0.285	0.499	.006	19	view →
PDAC	DFS	Median	III,IV	0.468	0.845	.023	8	view →
LUAD	OS	Quartile	II,III,IV	0.413	0.795	.010	6	view →
LSCC	DFS	Tertile	II,III,IV	0.518	0.855	.022	3	view →
HNSC	DFS	Tertile	II,III,IV	0.664	0.851	.042	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

FLNC–CCRCC (DFS)

Open the CCRCC breakdown →