Across TCGA pan-cancer cohorts, FLNA mass-spec protein differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of FLNA’s most consistent transcriptional readouts.
The strongest signal is observed in colon adenocarcinoma (COAD), where FLNA mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types FLNA is over-expressed in tumor, although a few such as COAD and LUAD show the opposite, repressed pattern.
COAD, HNSC, and LUAD are the cancer types where FLNA tumor–normal differential expression is most reproducible.
mass-spec protein tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FLNA mass-spec protein (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.