Across TCGA patient cohorts, FLNA RNA expression is significantly associated with the protein abundance of many other proteins, with 16,993 significant associations in total. GBM shows the largest number of these associations.

The most reproducible FLNA-associated proteins across cancer lineages are CNN2, FLNA_S2152, and RSU1. Each is linked with FLNA in more than 8 cancer types. Because this analysis shows association rather than direction, both FLNA-to-partner and partner-to-FLNA results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (FLNA→partner) and Y-score (partner→FLNA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	CNN2 →	+0.645	+0.606	<.001	<.001	3	9
BRCA	FLNA_S2152 →	+0.879	+1.298	<.001	<.001	3	9
OV	RSU1 →	+0.403	+1.647	<.001	<.001	3	8
BRCA	ACTN1 →	+0.556	+1.125	<.001	<.001	3	8
CCRCC	C1R →	+0.697	+0.631	<.001	<.001	3	8
PDAC	DAPK3 →	+0.527	+0.751	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,993 associations by consensus.

Exploration

FLNA survival (RNA) · tumor vs normal (RNA) · all FLNA data types