Across TCGA patient cohorts, FLNA protein abundance is significantly associated with the RNA expression of many other genes, with 18,881 significant associations in total. GBM shows the largest number of these associations.

The most reproducible FLNA-associated genes across cancer lineages are MYL9, ACTA2, and PRRX1. Each is linked with FLNA in more than 9 cancer types. Because this analysis shows association rather than direction, both FLNA-to-partner and partner-to-FLNA results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FLNA→partner) and Y-score (partner→FLNA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MYL9 →	+1.398	+0.747	<.001	<.001	3	10
OV	ACTA2 →	+2.233	+0.692	<.001	<.001	3	10
OV	PRRX1 →	+2.187	+0.645	<.001	<.001	3	10
OV	CALD1 →	+1.494	+0.655	<.001	<.001	3	10
CCRCC	ISLR →	+1.826	+0.490	<.001	<.001	3	10
UCEC	CNN1 →	+2.687	+0.857	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,881 associations by consensus.

Exploration

FLNA survival (RNA) · tumor vs normal (RNA) · all FLNA data types