Across TCGA patient cohorts, FLNA mutation is significantly associated with the total protein of many other genes, with 92 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FLNA-associated genes across cancer lineages are Cyclin-B1, Caspase-7-cleavedD198, and ERK2. Each is linked with FLNA in more than 5 cancer types. Because this analysis shows association rather than direction, both FLNA-to-partner and partner-to-FLNA results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FLNA→partner) and Y-score (partner→FLNA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	Cyclin-B1 →	+0.710	+2.000	<.001	.031	3	6
COAD	Caspase-7-cleavedD198 →	+1.118	+2.239	<.001	.004	3	5
LUAD	ERK2 →	+0.319	+3.169	.023	.018	3	4
LUAD	4E-BP1 →	+0.358	+2.000	.004	.031	3	4
LUAD	Cyclin-E1 →	+0.276	+3.000	.012	.034	3	4
COAD	c-Kit →	-0.504	-2.115	.013	.017	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 92 associations by consensus.

Exploration

FLNA survival (RNA) · tumor vs normal (RNA) · all FLNA data types