Across TCGA cell cohorts, FLNA RNA expression is significantly associated with the go_rna of many other GO terms, with 6,130 significant associations in total. BONE shows the largest number of these associations.

The most reproducible FLNA-associated GO terms across cancer lineages are Positive regulation of actin filament bundle assembly, Blood coagulation, fibrin clot formation, and Positive regulation of stress fiber assembly. Each is linked with FLNA in more than 17 cancer types. Because this analysis shows association rather than direction, both FLNA-to-partner and partner-to-FLNA results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FLNA→partner) and Y-score (partner→FLNA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of actin filament bundle assembly →	+0.157	+1.369	<.001	<.001	3	18
OESOPHAGUS	Blood coagulation, fibrin clot formation →	+0.407	+1.708	<.001	<.001	3	17
BONE	Positive regulation of stress fiber assembly →	+0.149	+1.441	<.001	<.001	3	17
LIVER	Regulation of plasminogen activation →	+0.398	+2.915	<.001	<.001	3	16
BONE	Integrin-mediated signaling pathway →	+0.207	+1.234	<.001	<.001	3	16
LUNG_NSCLC_LUSC	Protein activation cascade →	+0.353	+1.776	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,130 associations by consensus.

Exploration

FLNA survival (RNA) · tumor vs normal (RNA) · all FLNA data types