Across TCGA cell cohorts, FLNA mutation is significantly associated with the RNA expression of many other genes, with 1,948 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible FLNA-associated genes across cancer lineages are KLHL15, GLOD4, and SMYD4. Each is linked with FLNA in more than 3 cancer types. Because this analysis shows association rather than direction, both FLNA-to-partner and partner-to-FLNA results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FLNA→partner) and Y-score (partner→FLNA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	KLHL15 →	+0.612	+3.220	.006	.005	3	4
OVARY	GLOD4 →	+0.732	+3.099	<.001	.005	3	4
BLOOD_Leukemia	SMYD4 →	+0.689	+3.321	<.001	.005	3	4
LARGE_INTESTINE	MTFMT →	+0.499	+1.850	.001	.006	3	4
LARGE_INTESTINE	PDS5A →	+0.468	+2.459	.004	.006	3	4
BLOOD_Leukemia	ZBED3 →	+0.942	+2.252	.003	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,948 associations by consensus.

Exploration

FLNA survival (RNA) · tumor vs normal (RNA) · all FLNA data types