Across TCGA cell cohorts, FLNA mutation is significantly associated with the mutation status of many other genes, with 5,510 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FLNA-associated genes across cancer lineages are HECW2, PTPRN2, and KALRN. Each is linked with FLNA in more than 6 cancer types. Because this analysis shows association rather than direction, both FLNA-to-partner and partner-to-FLNA results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FLNA→partner) and Y-score (partner→FLNA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	HECW2 →	+2.752	+2.847	.005	.005	1	7
PANCREAS	PTPRN2 →	+5.115	+5.115	.005	.005	1	6
PANCREAS	KALRN →	+5.115	+5.115	.005	.005	1	6
BONE	PDCD11 →	+5.000	+4.437	.007	.007	1	6
STOMACH	KIF21B →	+4.209	+3.000	.002	.002	1	6
UPPER_AERODIGESTIVE_TRACT	CLUH →	+4.442	+3.217	.004	.004	1	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,510 associations by consensus.

Exploration

FLNA survival (RNA) · tumor vs normal (RNA) · all FLNA data types