FLII

Across TCGA patient cohorts, FLII mutation is significantly associated with the RNA expression of many other genes, with 2,582 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FLII-associated genes across cancer lineages are MCRIP2, BLOC1S2, and CPNE1. Each is linked with FLII in more than 2 cancer types. Because this analysis shows association rather than direction, both FLII-to-partner and partner-to-FLII results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MCRIP2 grouped by FLII-low versus FLII-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FLII→partner) and Y-score (partner→FLII) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MCRIP2 →	+0.392	+2.337	.002	<.001	3	3
COAD	BLOC1S2 →	+0.527	+3.459	.002	.005	3	3
COAD	CPNE1 →	-0.852	-3.446	.002	.005	3	3
COAD	MCUB →	+0.954	+3.362	<.001	.004	3	3
COAD	TIMM21 →	+0.639	+3.472	<.001	.002	3	3
UCEC	MYO15B →	-0.486	-1.357	.008	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,582 associations by consensus.

MCRIP2 by FLII expression — UCEC

Explore this box plot interactively →