FLII

Across TCGA patient cohorts, FLII mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FLII-associated genes across cancer lineages are TIGAR, ATM, and Caspase-7-cleavedD198. Each is linked with FLII in more than 2 cancer types. Because this analysis shows association rather than direction, both FLII-to-partner and partner-to-FLII results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TIGAR grouped by FLII-low versus FLII-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FLII→partner) and Y-score (partner→FLII) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TIGAR →	+0.108	+1.833	.038	.002	3	3
COAD	ATM →	-0.670	-3.000	<.001	.035	3	3
COAD	Caspase-7-cleavedD198 →	+1.867	+3.008	<.001	.019	3	3
UCEC	eEF2 →	+0.399	+3.700	.001	.001	3	2
UCEC	EGFR_pY1068 →	-0.244	-1.807	.004	.004	3	2
UCEC	eIF4E →	+0.168	+3.598	.019	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

TIGAR by FLII expression — UCEC

Explore this box plot interactively →