FLII

Across TCGA cell cohorts, FLII mutation is significantly associated with the RNA expression of many other genes, with 146 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FLII-associated genes across cancer lineages are GPR6, TAAR6, and KCNK16. Each is linked with FLII in more than 1 cancer types. Because this analysis shows association rather than direction, both FLII-to-partner and partner-to-FLII results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GPR6 grouped by FLII-low versus FLII-high in KIDNEY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FLII→partner) and Y-score (partner→FLII) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	GPR6 →	+0.033	+5.000	<.001	.005	3	1
BLOOD_Myeloma	TAAR6 →	+0.043	+4.807	<.001	.006	3	1
BLOOD_Myeloma	KCNK16 →	+0.030	+4.807	<.001	.006	3	1
UPPER_AERODIGESTIVE_TRACT	IZUMO1R →	+0.053	+4.736	<.001	.009	3	1
UPPER_AERODIGESTIVE_TRACT	FABP9 →	+0.060	+5.357	<.001	.003	3	1
LUNG_NSCLC_LUAD	OR1A2 →	+0.008	+3.681	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 146 associations by consensus.

GPR6 by FLII expression — KIDNEY

Explore this box plot interactively →