FLI1

Across TCGA patient cohorts, FLI1 mutation is significantly associated with the RNA expression of many other genes, with 3,039 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FLI1-associated genes across cancer lineages are RAD51, GINS3, and CDCA2. Each is linked with FLI1 in more than 3 cancer types. Because this analysis shows association rather than direction, both FLI1-to-partner and partner-to-FLI1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RAD51 grouped by FLI1-low versus FLI1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FLI1→partner) and Y-score (partner→FLI1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RAD51 →	+0.733	+2.069	<.001	<.001	3	4
UCEC	GINS3 →	+0.395	+2.080	.002	<.001	3	3
SKCM	CDCA2 →	+0.875	+3.182	<.001	.009	3	3
UCEC	GAS2L1 →	+0.438	+1.523	.001	.008	3	3
LUSC	GNPDA1 →	+0.463	+2.854	<.001	.001	3	3
UCEC	COX15 →	+0.425	+2.592	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,039 associations by consensus.

RAD51 by FLI1 expression — UCEC

Explore this box plot interactively →