FLI1

Across TCGA patient cohorts, FLI1 mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FLI1-associated genes across cancer lineages are ATM, eEF2, and A-Raf_pS299. Each is linked with FLI1 in more than 2 cancer types. Because this analysis shows association rather than direction, both FLI1-to-partner and partner-to-FLI1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by FLI1-low versus FLI1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FLI1→partner) and Y-score (partner→FLI1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ATM →	-0.942	-3.000	<.001	.035	2	3
UCEC	eEF2 →	+0.348	+2.584	.005	.010	3	2
UCEC	A-Raf_pS299 →	-0.083	-1.807	.044	.025	3	2
UCEC	TIGAR →	+0.129	+1.763	.015	.004	3	2
UCEC	Caspase-7-cleavedD198 →	+0.483	+2.135	.018	.010	3	2
UCEC	Di-Ras3 →	-0.127	-2.446	.013	.018	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

ATM by FLI1 expression — COAD

Explore this box plot interactively →