FLI1

Across TCGA cell cohorts, FLI1 mutation is significantly associated with the RNA expression of many other genes, with 80 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FLI1-associated genes across cancer lineages are CALHM4, DEFB108B, and PRAMEF7. Each is linked with FLI1 in more than 1 cancer types. Because this analysis shows association rather than direction, both FLI1-to-partner and partner-to-FLI1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CALHM4 grouped by FLI1-low versus FLI1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FLI1→partner) and Y-score (partner→FLI1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CALHM4 →	+0.038	+5.269	<.001	<.001	3	1
BLOOD_Leukemia	DEFB108B →	+0.161	+5.269	<.001	<.001	3	1
BLOOD_Leukemia	PRAMEF7 →	+0.009	+4.539	.008	.007	3	1
BLOOD_Lymphoma	KLHL40 →	+0.006	+5.209	.006	.005	3	1
BLOOD_Lymphoma	C1orf87 →	+0.021	+4.867	.008	.009	3	1
SKIN	GUCA2A →	+0.065	+4.273	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 80 associations by consensus.

CALHM4 by FLI1 expression — BLOOD_Leukemia

Explore this box plot interactively →