FLAD1

Across TCGA pan-cancer cohorts, FLAD1 Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated FLAD1 data layer compared with 27 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher FLAD1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated FLAD1 expression acts as an unfavorable survival marker, although some lineages such as SKCM and LGG show a favorable association.

HNSC, KIRC, and COAD are the cancer types where FLAD1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.259	0.688	.005	45	view →
KIRC	OS	Median	All	0.054	0.881	<.001	30	view →
COAD	OS	Median	All	0.172	0.870	<.001	12	view →
ACC	DFS	Median	All	0.195	0.748	.003	3	view →
SKCM	DFS	Median	II,III,IV	0.894	0.668	.027	3	view →
LGG	OS	Median	All	1.000	0.421	.023	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

FLAD1–HNSC (OS)

Open the HNSC breakdown →