FLAD1

Across TCGA cell cohorts, FLAD1 mutation is significantly associated with the mutation status of many other genes, with 2,802 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible FLAD1-associated genes across cancer lineages are RECQL, ST6GALNAC2, and RGS11. Each is linked with FLAD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both FLAD1-to-partner and partner-to-FLAD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RECQL grouped by FLAD1-low versus FLAD1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FLAD1→partner) and Y-score (partner→FLAD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	RECQL →	+3.087	+4.392	.005	.005	1	2
LARGE_INTESTINE	ST6GALNAC2 →	+3.350	+4.584	.003	.003	1	2
LARGE_INTESTINE	RGS11 →	+4.087	+5.044	.001	.001	1	2
BLOOD_Leukemia	PCDHB2 →	+2.690	+2.762	.005	.005	1	2
BLOOD_Leukemia	SLC12A7 →	+2.846	+3.766	<.001	<.001	1	2
BLOOD_Leukemia	NR3C1 →	+2.650	+2.960	.001	.001	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,802 associations by consensus.

RECQL by FLAD1 expression — LARGE_INTESTINE

Explore this box plot interactively →