FKTN

Across TCGA patient cohorts, FKTN mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FKTN-associated genes across cancer lineages are 14-3-3_beta, ACVRL1, and JNK2. Each is linked with FKTN in more than 1 cancer types. Because this analysis shows association rather than direction, both FKTN-to-partner and partner-to-FKTN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by FKTN-low versus FKTN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FKTN→partner) and Y-score (partner→FKTN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.135	-2.571	.003	.011	2	2
UCEC	ACVRL1 →	-0.133	-2.302	.037	.034	3	1
UCEC	JNK2 →	+0.283	+2.469	.002	.010	3	1
UCEC	Myosin-IIa_pS1943 →	+0.195	+2.598	.042	.006	3	1
UCEC	Rab25 →	-0.341	-2.584	.027	.011	3	1
UCEC	Annexin-1 →	+0.838	+3.341	<.001	.005	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

14-3-3_beta by FKTN expression — UCEC

Explore this box plot interactively →