FKRP

Across TCGA patient cohorts, FKRP mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FKRP-associated genes across cancer lineages are STAT3_pY705, EGFR_pY1068, and A-Raf_pS299. Each is linked with FKRP in more than 1 cancer types. Because this analysis shows association rather than direction, both FKRP-to-partner and partner-to-FKRP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by FKRP-low versus FKRP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FKRP→partner) and Y-score (partner→FKRP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.337	-2.311	.003	.034	3	2
UCEC	EGFR_pY1068 →	-0.262	-2.115	.016	.019	3	1
UCEC	A-Raf_pS299 →	-0.146	-2.115	.005	.019	3	1
UCEC	IGFBP2 →	-0.739	-2.115	.009	.019	3	1
UCEC	JNK2 →	+0.241	+2.834	.005	.034	3	1
UCEC	Ku80 →	+0.248	+1.598	.016	.044	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

STAT3_pY705 by FKRP expression — UCEC

Explore this box plot interactively →