Across TCGA pan-cancer cohorts, FKBPL mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of FKBPL’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where FKBPL mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types FKBPL is over-expressed in tumor, although a few such as LUAD and PDAC show the opposite, repressed pattern.

CCRCC, LUAD, and PDAC are the cancer types where FKBPL tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FKBPL mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Male	All	+0.418	<.001	8	view →
LUAD	All	All	−0.095	<.001	5	view →
PDAC	Male	All	−0.376	.001	4	view →
HNSC	Male	IV	−0.135	.049	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: FKBPL RNA expression & survival · all FKBPL data types