FKBP9

Across TCGA patient cohorts, FKBP9 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FKBP9-associated genes across cancer lineages are Shc_pY317, C-Raf, and EGFR_pY1068. Each is linked with FKBP9 in more than 1 cancer types. Because this analysis shows association rather than direction, both FKBP9-to-partner and partner-to-FKBP9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Shc_pY317 grouped by FKBP9-low versus FKBP9-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FKBP9→partner) and Y-score (partner→FKBP9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Shc_pY317 →	-0.186	-1.736	<.001	.007	3	2
UCEC	C-Raf →	+0.184	+2.502	<.001	.001	3	2
UCEC	EGFR_pY1068 →	-0.259	-2.700	.002	.005	3	1
UCEC	A-Raf_pS299 →	-0.158	-2.807	<.001	.003	3	1
UCEC	ERK2 →	+0.188	+1.700	.004	.040	3	1
UCEC	Fibronectin →	-0.225	-1.575	.049	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

Shc_pY317 by FKBP9 expression — UCEC

Explore this box plot interactively →