FKBP8

Across TCGA pan-cancer cohorts, FKBP8 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated FKBP8 data layer compared with 21 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher FKBP8 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated FKBP8 expression acts as an unfavorable survival marker, although some lineages such as GBM show a favorable association.

PDAC, CCRCC, and LUAD are the cancer types where FKBP8 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Median	III,IV	0.471	1.000	.002	39	view →
CCRCC	DFS	Median	III,IV	0.472	0.815	.001	31	view →
LUAD	DFS	Median	III,IV	0.409	0.941	.010	7	view →
HNSC	DFS	Tertile	IV	0.471	0.763	.020	4	view →
UCEC	DFS	Quartile	All	0.798	0.943	.046	2	view →
LSCC	OS	Median	II,III,IV	0.810	1.000	.035	2	view →
GBM	DFS	Quartile	All	0.868	0.644	.040	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

FKBP8–PDAC (OS)

Open the PDAC breakdown →