FKBP8

Across TCGA patient cohorts, FKBP8 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FKBP8-associated genes across cancer lineages are MEK1, PDCD4, and A-Raf_pS299. Each is linked with FKBP8 in more than 1 cancer types. Because this analysis shows association rather than direction, both FKBP8-to-partner and partner-to-FKBP8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by FKBP8-low versus FKBP8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FKBP8→partner) and Y-score (partner→FKBP8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.406	+2.321	.007	.006	3	2
UCEC	PDCD4 →	-0.471	-1.807	.015	.027	3	2
UCEC	A-Raf_pS299 →	-0.110	-2.000	.026	.030	3	1
UCEC	Heregulin →	-0.113	-3.156	.027	.018	3	1
UCEC	Notch1 →	+0.146	+3.009	.012	.019	3	1
UCEC	p62 Lck ligand →	+0.468	+2.469	<.001	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

MEK1 by FKBP8 expression — UCEC

Explore this box plot interactively →