FKBP5

Across TCGA pan-cancer cohorts, FKBP5 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated FKBP5 data layer compared with 25 for mass-spec protein and 7 for mass-spec protein.

The strongest signal is observed in lymphoid neoplasm diffuse large b-cell lymphoma (DLBC), where higher FKBP5 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated FKBP5 expression acts as an unfavorable survival marker, although some lineages such as SKCM show a favorable association.

DLBC, LUAD, and SKCM are the cancer types where FKBP5 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
DLBC	DFS	Median	II,III,IV	0.065	0.829	<.001	24	view →
LUAD	OS	Median	All	0.323	0.834	.003	6	view →
SKCM	DFS	Median	III,IV	1.000	0.577	.034	3	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

FKBP5–DLBC (DFS)

Open the DLBC breakdown →