FKBP5

Across TCGA pan-cancer cohorts, FKBP5 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated FKBP5 data layer compared with 25 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher FKBP5 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated FKBP5 expression acts as an unfavorable survival marker, although some lineages such as PDAC and UCEC show a favorable association.

CCRCC, HNSC, and GBM are the cancer types where FKBP5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Tertile	All	0.662	0.960	<.001	57	view →
HNSC	DFS	Tertile	II,III,IV	0.646	0.895	.001	22	view →
GBM	DFS	Quartile	All	0.581	0.869	<.001	15	view →
LSCC	DFS	Median	III,IV	0.448	0.909	.020	11	view →
PDAC	DFS	Tertile	IV	0.934	0.203	.024	6	view →
OV	DFS	Median	All	0.842	1.000	.024	4	view →
UCEC	OS	Median	All	0.980	0.850	.009	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

FKBP5–CCRCC (OS)

Open the CCRCC breakdown →