FKBP5

Across TCGA patient cohorts, FKBP5 mutation is significantly associated with the RNA expression of many other genes, with 5,425 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FKBP5-associated genes across cancer lineages are RPL21P109, MIR103A1, and RN7SKP231. Each is linked with FKBP5 in more than 2 cancer types. Because this analysis shows association rather than direction, both FKBP5-to-partner and partner-to-FKBP5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPL21P109 grouped by FKBP5-low versus FKBP5-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FKBP5→partner) and Y-score (partner→FKBP5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RPL21P109 →	+0.054	+3.558	.001	.005	3	3
COAD	MIR103A1 →	+0.950	+5.136	<.001	.002	3	3
COAD	RN7SKP231 →	+0.571	+4.666	<.001	.005	3	3
COAD	RNU6-522P →	+0.751	+4.807	<.001	.004	3	3
UCEC	RPS3AP17 →	+0.051	+1.899	.006	.004	3	3
UCEC	GTF3C6P3 →	+0.131	+1.709	.007	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,425 associations by consensus.

RPL21P109 by FKBP5 expression — BLCA

Explore this box plot interactively →