FKBP5

Across TCGA patient cohorts, FKBP5 mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FKBP5-associated genes across cancer lineages are Cyclin-E2, eIF4G, and Gab2. Each is linked with FKBP5 in more than 2 cancer types. Because this analysis shows association rather than direction, both FKBP5-to-partner and partner-to-FKBP5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-E2 grouped by FKBP5-low versus FKBP5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FKBP5→partner) and Y-score (partner→FKBP5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-E2 →	+0.122	+1.440	.036	.024	3	3
UCEC	eIF4G →	+0.274	+2.459	.010	.018	3	2
UCEC	Gab2 →	+0.334	+1.440	.006	.024	3	2
UCEC	JNK2 →	+0.211	+2.026	.002	.016	3	2
UCEC	mTOR_pS2448 →	-0.123	-1.986	.017	.029	3	2
UCEC	Notch1 →	+0.140	+2.070	.004	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

Cyclin-E2 by FKBP5 expression — UCEC

Explore this box plot interactively →