FKBP5

Across TCGA cell cohorts, FKBP5 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,359 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible FKBP5-associated GO terms across cancer lineages are Defense response to bacterium, DNA replication, and DNA-templated DNA replication. Each is linked with FKBP5 in more than 11 cancer types. Because this analysis shows association rather than direction, both FKBP5-to-partner and partner-to-FKBP5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Defense response to bacterium grouped by FKBP5-low versus FKBP5-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FKBP5→partner) and Y-score (partner→FKBP5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Defense response to bacterium →	-0.133	-1.723	<.001	<.001	3	11
LIVER	DNA replication →	+0.070	+1.272	.004	.002	3	11
BLOOD_Lymphoma	DNA-templated DNA replication →	+0.111	+1.351	<.001	.003	2	12
LARGE_INTESTINE	DNA replication initiation →	+0.134	+1.485	<.001	<.001	3	11
BLOOD_Lymphoma	Protein-DNA complex disassembly →	+0.148	+1.397	<.001	<.001	3	10
LIVER	Negative regulation of RNA export from nucleus →	+0.130	+1.393	.002	.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,359 associations by consensus.

Defense response to bacterium by FKBP5 expression — PANCREAS

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