FKBP2

Across TCGA pan-cancer cohorts, FKBP2 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of FKBP2’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where FKBP2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types FKBP2 is over-expressed in tumor, although a few such as THCA and COAD show the opposite, repressed pattern.

LIHC, HNSC, and LUAD are the cancer types where FKBP2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FKBP2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	All	II,III,IV	+0.766	<.001	7	view →
HNSC	Male	All	+0.548	<.001	7	view →
LUAD	All	II,III,IV	+0.531	.001	6	view →
THCA	Male	All	−0.590	.002	5	view →
COAD	All	All	−0.254	.011	5	view →
STAD	All	All	+0.391	.003	4	view →
BLCA	All	All	+0.292	.013	4	view →
READ	All	All	−1.030	.003	3	view →
BRCA	Female	All	+0.347	.020	2	view →
CHOL	Female	All	+0.723	.036	1	view →
ESCA	All	All	+0.369	.048	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

FKBP2–LIHC

Open the LIHC breakdown →