FKBP15

Across TCGA pan-cancer cohorts, FKBP15 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated FKBP15 data layer compared with 26 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher FKBP15 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated FKBP15 expression acts as an unfavorable survival marker, although some lineages such as HNSC and PDAC show a favorable association.

HNSC, COAD, and GBM are the cancer types where FKBP15 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	IV	1.000	0.924	.037	8	view →
COAD	DFS	Tertile	All	0.923	1.000	.034	6	view →
GBM	DFS	Tertile	All	0.628	0.851	.005	4	view →
PDAC	OS	Tertile	All	0.981	0.799	.021	2	view →
LSCC	OS	Median	II,III,IV	1.000	0.904	.021	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

FKBP15–HNSC (DFS)

Open the HNSC breakdown →