FKBP15

Across TCGA patient cohorts, FKBP15 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FKBP15-associated genes across cancer lineages are p38-MAPK_pT180_Y182, PCNA, and 4E-BP1. Each is linked with FKBP15 in more than 2 cancer types. Because this analysis shows association rather than direction, both FKBP15-to-partner and partner-to-FKBP15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p38-MAPK_pT180_Y182 grouped by FKBP15-low versus FKBP15-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FKBP15→partner) and Y-score (partner→FKBP15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p38-MAPK_pT180_Y182 →	-0.506	-2.321	.001	.005	3	3
UCEC	PCNA →	+0.182	+2.459	.016	.018	3	3
UCEC	4E-BP1 →	+0.346	+2.837	<.001	.001	3	3
UCEC	Cyclin-B1 →	+0.505	+2.584	.010	.010	3	3
UCEC	Cyclin-E2 →	+0.136	+2.115	.022	.016	3	3
UCEC	JNK_pT183_Y185 →	-0.206	-1.986	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

p38-MAPK_pT180_Y182 by FKBP15 expression — UCEC

Explore this box plot interactively →