FKBP15

Across TCGA cell cohorts, FKBP15 mutation is significantly associated with the RNA expression of many other genes, with 463 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FKBP15-associated genes across cancer lineages are BHLHA9, PLA2G2E, and C3orf84. Each is linked with FKBP15 in more than 1 cancer types. Because this analysis shows association rather than direction, both FKBP15-to-partner and partner-to-FKBP15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BHLHA9 grouped by FKBP15-low versus FKBP15-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FKBP15→partner) and Y-score (partner→FKBP15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	BHLHA9 →	+0.050	+4.273	<.001	.006	3	1
BREAST	PLA2G2E →	+0.036	+5.781	<.001	.001	3	1
BREAST	C3orf84 →	+0.058	+5.169	<.001	.005	3	1
BLOOD_Leukemia	MYH13 →	+0.798	+3.705	<.001	.007	3	1
LARGE_INTESTINE	GRK3 →	+0.879	+2.451	<.001	.009	3	1
LARGE_INTESTINE	CCDC134 →	+0.807	+3.131	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 463 associations by consensus.

BHLHA9 by FKBP15 expression — SKIN

Explore this box plot interactively →