FIZ1

Across TCGA pan-cancer cohorts, FIZ1 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated FIZ1 data layer compared with 28 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher FIZ1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated FIZ1 expression acts as an unfavorable survival marker, although some lineages such as LSCC and CCRCC show a favorable association.

PDAC, LSCC, and CCRCC are the cancer types where FIZ1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Median	II,III,IV	0.371	0.685	<.001	78	view →
LSCC	DFS	Tertile	All	1.000	0.931	.013	5	view →
CCRCC	DFS	Median	III,IV	0.958	0.774	.017	3	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

FIZ1–PDAC (OS)

Open the PDAC breakdown →