Across TCGA patient cohorts, FITM2 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FITM2-associated genes across cancer lineages are EGFR_pY1068, Lck, and MEK1. Each is linked with FITM2 in more than 1 cancer types. Because this analysis shows association rather than direction, both FITM2-to-partner and partner-to-FITM2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FITM2→partner) and Y-score (partner→FITM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.283	-3.169	.024	.019	3	1
UCEC	Lck →	+0.255	+2.321	.011	.035	3	1
UCEC	MEK1 →	+0.462	+3.000	.011	.036	3	1
UCEC	Myosin-IIa_pS1943 →	+0.252	+3.472	.015	.002	3	1
UCEC	p62 Lck ligand →	+0.474	+3.179	.003	.010	3	1
UCEC	PDCD4 →	-0.531	-3.459	.024	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

Exploration

FITM2 survival (RNA) · tumor vs normal (RNA) · all FITM2 data types