FITM1

Across TCGA patient cohorts, FITM1 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FITM1-associated genes across cancer lineages are ERK2, GSK-3_pS9, and JNK2. Each is linked with FITM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both FITM1-to-partner and partner-to-FITM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by FITM1-low versus FITM1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FITM1→partner) and Y-score (partner→FITM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.217	+2.999	.031	.035	3	1
UCEC	GSK-3_pS9 →	-0.572	-3.169	.006	.019	3	1
UCEC	JNK2 →	+0.340	+3.321	.001	.010	3	1
UCEC	MEK1 →	+0.509	+3.169	.007	.019	3	1
UCEC	mTOR_pS2448 →	-0.196	-3.321	.012	.010	3	1
UCEC	p62 Lck ligand →	+0.562	+3.321	<.001	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

ERK2 by FITM1 expression — UCEC

Explore this box plot interactively →