Across TCGA pan-cancer cohorts, FIS1 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated FIS1 data layer compared with 23 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher FIS1 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated FIS1 expression acts as an unfavorable survival marker.

COAD, GBM, and SKCM are the cancer types where FIS1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	All	0.189	0.785	<.001	30	view →
GBM	OS	Median	All	0.030	0.416	<.001	12	view →
SKCM	DFS	Median	All	0.046	0.728	<.001	3	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: FIS1 tumor-vs-normal RNA expression · all FIS1 data types