Across TCGA patient cohorts, FIS1 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FIS1-associated genes across cancer lineages are ERK2, IGFBP2, and Notch1. Each is linked with FIS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both FIS1-to-partner and partner-to-FIS1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FIS1→partner) and Y-score (partner→FIS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.179	+2.000	.039	.032	3	1
UCEC	IGFBP2 →	-0.650	-3.000	.026	.036	3	1
UCEC	Notch1 →	+0.146	+2.820	.021	.035	3	1
UCEC	p38-MAPK →	-0.199	-2.439	.007	.019	3	1
UCEC	STAT3_pY705 →	-0.353	-2.700	.002	.006	3	1
UCEC	YAP_pS127 →	+0.312	+2.000	.033	.032	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

Exploration

FIS1 survival (RNA) · tumor vs normal (RNA) · all FIS1 data types