Across TCGA pan-cancer cohorts, FIRRE RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of FIRRE’s most consistent transcriptional readouts.
The strongest signal is observed in colon adenocarcinoma (COAD), where FIRRE RNA is more highly expressed in tumor relative to normal tissue. In most cancer types FIRRE is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.
COAD, HNSC, and KIRC are the cancer types where FIRRE tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FIRRE RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.