FIP1L1

Across TCGA patient cohorts, FIP1L1 protein abundance is significantly associated with the RNA expression of many other genes, with 12,068 significant associations in total. GBM shows the largest number of these associations.

The most reproducible FIP1L1-associated genes across cancer lineages are BRCA1, CCT3, and TMPO. Each is linked with FIP1L1 in more than 5 cancer types. Because this analysis shows association rather than direction, both FIP1L1-to-partner and partner-to-FIP1L1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, FIP1L1 versus BRCA1 in UCEC, with a Pearson correlation of 0.38.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FIP1L1→partner) and Y-score (partner→FIP1L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	BRCA1 →	+0.884	+0.199	.001	<.001	3	6
UCEC	CCT3 →	+0.926	+0.200	<.001	.001	3	6
GBM	TMPO →	+0.912	+0.656	<.001	<.001	3	6
LSCC	PPAT →	+0.817	+0.251	<.001	<.001	3	6
UCEC	ZC3H8 →	+0.580	+0.218	<.001	<.001	3	6
GBM	NUP35 →	+0.572	+0.576	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,068 associations by consensus.

FIP1L1 vs BRCA1 — UCEC

Explore this scatter interactively →