FIP1L1

Across TCGA patient cohorts, FIP1L1 mutation is significantly associated with the RNA expression of many other genes, with 1,724 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FIP1L1-associated genes across cancer lineages are CCDC3, MFSD12, and IFI27L1. Each is linked with FIP1L1 in more than 1 cancer types. Because this analysis shows association rather than direction, both FIP1L1-to-partner and partner-to-FIP1L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCDC3 grouped by FIP1L1-low versus FIP1L1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FIP1L1→partner) and Y-score (partner→FIP1L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CCDC3 →	-0.765	-2.523	.001	<.001	3	2
UCEC	MFSD12 →	+0.426	+2.169	.002	<.001	3	2
UCEC	IFI27L1 →	+0.381	+2.243	.007	.005	3	2
LIHC	TSPY18P →	+0.101	+4.758	<.001	.006	3	2
UCEC	RNF126 →	+0.459	+4.119	<.001	<.001	3	2
UCEC	TCOF1 →	+0.337	+2.595	.008	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,724 associations by consensus.

CCDC3 by FIP1L1 expression — UCEC

Explore this box plot interactively →