FIP1L1

Across TCGA patient cohorts, FIP1L1 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FIP1L1-associated genes across cancer lineages are Caspase-7-cleavedD198, cIAP, and VEGFR2. Each is linked with FIP1L1 in more than 1 cancer types. Because this analysis shows association rather than direction, both FIP1L1-to-partner and partner-to-FIP1L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by FIP1L1-low versus FIP1L1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FIP1L1→partner) and Y-score (partner→FIP1L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.529	+1.604	.017	.041	3	2
UCEC	cIAP →	+0.132	+2.594	.010	.006	3	2
LUSC	VEGFR2 →	+0.538	+2.834	<.001	.035	3	1
UCEC	EGFR_pY1068 →	-0.223	-1.807	.017	.025	3	1
UCEC	ERK2 →	+0.151	+3.169	.036	.018	3	1
UCEC	JNK2 →	+0.287	+2.817	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

Caspase-7-cleavedD198 by FIP1L1 expression — UCEC

Explore this box plot interactively →