FIP1L1

Across TCGA cell cohorts, FIP1L1 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible FIP1L1-associated genes across cancer lineages are REG1B, IGSF21, and GFRA4. Each is linked with FIP1L1 in more than 1 cancer types. Because this analysis shows association rather than direction, both FIP1L1-to-partner and partner-to-FIP1L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, REG1B grouped by FIP1L1-low versus FIP1L1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FIP1L1→partner) and Y-score (partner→FIP1L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	REG1B →	+2.507	+4.196	<.001	.002	3	2
BLOOD_Lymphoma	IGSF21 →	+0.071	+3.843	.003	.007	3	1
BLOOD_Lymphoma	GFRA4 →	+0.015	+3.714	<.001	.006	3	1
BLOOD_Lymphoma	NMUR2 →	+1.014	+3.999	<.001	.004	3	1
BLOOD_Lymphoma	OR52E2 →	+0.116	+3.927	<.001	.004	3	1
BLOOD_Lymphoma	PABPC1L2A →	+0.019	+4.058	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

REG1B by FIP1L1 expression — LARGE_INTESTINE

Explore this box plot interactively →