FILIP1L

Across TCGA patient cohorts, FILIP1L mutation is significantly associated with the total protein of many other genes, with 54 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FILIP1L-associated genes across cancer lineages are ASNS, ATM, and Chk1. Each is linked with FILIP1L in more than 2 cancer types. Because this analysis shows association rather than direction, both FILIP1L-to-partner and partner-to-FILIP1L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by FILIP1L-low versus FILIP1L-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FILIP1L→partner) and Y-score (partner→FILIP1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	ASNS →	+0.634	+2.459	.001	.018	3	3
UCEC	ATM →	-0.618	-2.986	<.001	<.001	3	3
SKCM	Chk1 →	+0.276	+3.841	.001	<.001	3	2
UCEC	eEF2 →	+0.243	+1.137	.030	.041	3	2
UCEC	ERK2 →	+0.193	+2.321	.001	<.001	3	2
UCEC	GAPDH →	+0.405	+2.700	.016	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

ASNS by FILIP1L expression — SKCM

Explore this box plot interactively →