FIGN

Across TCGA patient cohorts, FIGN mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FIGN-associated genes across cancer lineages are Cyclin-B1, JNK2, and ATM. Each is linked with FIGN in more than 2 cancer types. Because this analysis shows association rather than direction, both FIGN-to-partner and partner-to-FIGN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by FIGN-low versus FIGN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FIGN→partner) and Y-score (partner→FIGN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.639	+2.070	.001	.001	3	3
UCEC	JNK2 →	+0.245	+1.736	<.001	.007	3	3
UCEC	ATM →	-0.690	-3.156	<.001	<.001	3	3
STAD	eIF4E →	+0.209	+2.828	.014	.033	3	2
STAD	Akt_pS473 →	-0.502	-2.984	.007	.034	3	2
STAD	beta-Catenin →	+0.711	+3.321	.037	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

Cyclin-B1 by FIGN expression — UCEC

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